Two-week pilots with measurable outcomes.

Inputs: amplicon set, genome build, edit intent

Week 0: Intake

Share targets, current CRISPR/Prime Editing workflows, NGS formats, and success metrics. We align on scope in a 45-minute working session.

Deliverable: evidence bundle + reproducibility hash

Week 1: Intent + Policy + Evidence

We recreate your edit intents inside Helix Studio, declare policies/constraints, and generate deterministic evidence bundles for review.

Deliverable: validated report + automation recipe

Week 2: NGS + Validation

You provide reads (BAM/FASTQ). We align inside Helix, compare with intent, and summarize QC + agreement metrics.

Validated designs

Sequence recipes, pegRNA scaffolds, donors, primers with deterministic hashes.

Benchmarked outcomes

Agreement table, edit efficiency deltas, runtime stats per hardware profile.

Integration notes

CLI scripts + API payloads for CI/CD or LIMS handoff.

Security pack

Signed build links, checksum + SBOM, telemetry/offline configuration.

Time saved

Baseline: spreadsheet + scripts workflow. Goal: >5× faster design-to-analysis loop. We share before/after timing sheets for each pilot.

Edit agreement

Prime Editing & CRISPR edits tracked against observed outcomes. Aim for <5% delta in indel spectrum agreement for targeted reads.

QC pass rate

At least 90% of reads must meet coverage + quality gates to green-light rollout. We share QC diffs + remediation guidance.